You will need experience of, an understanding of how USB to COM ports work, and how to 'passthrough' devices from the host computer to the virtual guest computer. If so, you can install and use the software natively. The best case scenario is that you have a Windows 95 or Windows 98 computer that has a COM (9-pin D serial) port and a genuine Kenwood serial-to-2-pin cable. These are simple notes to help you along. Basic Notes Radiotronics do not offer any training on radio programming. KPG-54D is relatively difficult software to run on a modern PC.
Kenwood KPG-54D is the programming software for PMR446 two way radio.